About

DSC_MRI_Analysis is an extension of 3D Slicer that implements fitting of various models to Dynamic Susceptibility MRI data. The module produces various (model-specific) voxel-wise parameter maps, and the accompanying diagnostic outputs to evaluate quality of the model fit. The module produces the following parameter maps:

• K2: leakage map
• RCBV: Relative Cerebral Blood Volume (rCBV) map
• RCBF: Relative Cerebral Blood Flow (rCBF) map
• MTT: Mean Transit Time (MTT) map

This extension can be used together with the MultiVolume Explorer module of 3D Slicer. MultiVolume Explorer module allows to interactively visualize the signal curve at the individual pixels, and also examine the quality of model fit relative to the original data.

Availability

Installation: DSC_MRI_Analysis can be accessed by installing the DSC_MRI_Analysis extension to 3D Slicer via 3D Slicer Extension manager.

Documentation: link

Source code: link

Publications

• Schmainda KM, Prah MA, Rand SD, et al. Multisite Concordance of DSC-MRI Analysis for Brain Tumors: Results of a National Cancer Institute Quantitative Imaging Network Collaborative Project. AJNR Am J Neuroradiol. 2018; http://dx.doi.org/10.3174/ajnr.A5675. - Quantitative Imaging Network (QIN) evaluation of DSC MRI modeling tools that included DSC_MRI_Analysis

Grants support

• U01 CA154601
• U24 CA180918